Chapter 3 Colon Cancer in Iceland - A nationwide
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چکیده
Increasing evidence suggests genetic, biological and demographical difference between right and left colon cancer. Studies have also indicated age differences in the pathology of colon cancer. There is a scarcity of large-scale studies that closely examine the pathological differences regarding age and tumor location. The aim of this study was to do an extensive comparison of rightand left-sided colon cancers as well as comparing patients <50 years with older patients. A retrospective, population-based study was carried out on all patients with colon cancer in Iceland between 1955 and 2004. A total of 2293 cases were analyzed (1148 males, 1145 females). All histopathology material was re-evaluated. Differences in tumor characteristics between right and left location and younger (<50) and older (≥50) patients were evaluated in particular. Higher TNM-stage, larger tumors, vessel invasion, mucinous type, high grade and expanding tumor border occurred more frequently in rightvs. left-sided lesions while annular and polypoid tumors were more common in left-sided tumors (p<0.05). Young patients had more frequent lymph node metastases, vessel invasion, non-polypoid lesions and infiltrating tumor border (p<0.05). Right-sided lesions show more aggressive features, reflected in morphology and stage. Younger patients present more frequently with adverse features than do older patients. Frequency of rightand left-sided colon cancer differs by age with pronounced age-location differences in females. This supports the assumption of differences in etiology and carcinogenesis of rightand left-sided colon cancer, and between young and old patients. Colon cancer: right vs. left, young vs. old | 41
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تاریخ انتشار 2016